Physiology, (Costanzo Physiology) by Linda S. Costanzo

Author:Linda S. Costanzo [Costanzo, Linda S.]
Language: eng
Format: mobi
Publisher: Elsevier Health Sciences
Published: 2013-05-27T04:00:00+00:00

EXPLANATION OF CASE. There are two possible explanations for this woman’s glucosuria: (1) a defect in the renal transport mechanism for glucose or (2) an increased filtered load of glucose that exceeds the reabsorptive capacity of the proximal tubule. To determine which explanation is correct, the maximal reabsorption rate for glucose (Tm) is determined by measuring the reabsorption rate as the plasma glucose concentration is increased. A value of Tm of 375 mg/min is found, which is considered normal. Thus, the physician concludes that the basis for the woman’s glucosuria is an abnormally elevated blood glucose concentration due to insufficient secretion of insulin from the pancreas. If the glucosuria had been caused by a renal defect, the Tm would be lower than normal.

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